Mitochondrial & Energy Peptides

Mitochondrial & Energy Peptide Research

Mitochondrial peptides target the powerhouse of the cell directly - protecting the inner membrane, restoring NAD+ levels, and activating metabolic pathways that decline with age. SS-31 (Elamipretide) is the most advanced mitochondria-targeting peptide in clinical development, while NAD+ supplementation addresses the coenzyme depletion that underlies age-related metabolic decline.

Key Research Highlights

SS-31 binds cardiolipin on the inner mitochondrial membrane, stabilizing electron transport chain function
NAD+ is essential for sirtuins, PARP enzymes, and over 500 metabolic reactions - levels decline ~50% between ages 40-60
PNC-27 contains a p53 binding domain that selectively targets cells with HDM2 membrane expression
For the mitochondrial-derived peptide MOTS-c, see our Longevity & Anti-Aging category

Product Comparison

Compound	Target	Mechanism	Dosages	Clinical Status
SS-31 (Elamipretide)	Cardiolipin	IMM stabilization, ETC optimization	10/27/47mg	Phase III (Barth syndrome)
NAD+	NAD+ pool	Direct NAD+ replenishment	500mg	Widely studied nutraceutical
PNC-27	HDM2 membrane	p53-derived membranolytic peptide	30mg	Preclinical research

Mitochondrial Targeting

Inner Membrane Protection

SS-31 is a cell-permeable tetrapeptide (D-Arg-Dmt-Lys-Phe-NH2) that concentrates 1000-fold in mitochondria. It binds cardiolipin at the inner mitochondrial membrane, preventing cytochrome c peroxidase activity and optimizing electron transport chain coupling, reducing ROS production at the source.

NAD+ and Sirtuins

NAD+ is required for sirtuin (SIRT1-7) activity, which regulates mitochondrial biogenesis, DNA repair, and metabolic homeostasis. Direct IV NAD+ supplementation bypasses the rate-limiting steps of oral precursors (NMN, NR), providing immediate cofactor availability for mitochondrial longevity pathways.

Preparation

SS-31 and PNC-27 require bacteriostatic water for reconstitution. NAD+ is supplied as a pH-buffered solution ready for research use. Use the reconstitution calculator and dosage calculator for lyophilized products.

Research Use Only: All mitochondrial compounds are sold for legitimate research purposes. Products are third-party tested. View quality assurance documentation.