Semax, Selank, NA variants, and neuropeptides for cognitive and neurological research.
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Nootropic peptides target the central nervous system to modulate cognition, memory consolidation, anxiety, and neuroprotection. Originally developed at the Institute of Molecular Genetics in Moscow, Semax and Selank have been prescribed in Russia as nootropic and anxiolytic medications since the 1990s. Their N-Acetyl Amidate derivatives offer enhanced bioavailability and blood-brain barrier penetration for advanced research applications.
| Peptide | Origin | Primary Mechanism | Research Focus |
|---|---|---|---|
| Semax | ACTH(4-10) fragment | BDNF upregulation | Cognition, memory, neuroprotection |
| Selank | Tuftsin analogue | GABA modulation | Anxiety, stress, immune function |
| NA-Semax Amidate | Modified Semax | Enhanced BDNF | Extended half-life, stronger BBB penetration |
| NA-Selank Amidate | Modified Selank | Enhanced GABA | Potent anxiolytic research |
| Pe-22-28 | Spadin analogue | TREK-1 blockade | Antidepressant, neurogenesis |
| IllumiNeuro Blend | Multi-peptide formula | Multi-pathway | Cognitive stacking research |
Cognitive peptides act through distinct neurotransmitter and neurotrophic pathways, offering researchers the ability to target specific aspects of brain function without the broad receptor binding seen in traditional psychoactive compounds.
Semax and its derivatives increase brain-derived neurotrophic factor (BDNF) expression, promoting dendritic branching, synaptic plasticity, and long-term potentiation - the cellular basis of learning and memory.
Selank enhances GABAergic transmission and modulates serotonin metabolism. Unlike benzodiazepines, it produces anxiolytic effects without sedation or dependence, making it a subject of significant psychiatric research interest.
Most nootropic peptides are administered intranasally in research settings due to the nasal mucosa's direct access to the CNS. Reconstitute with bacteriostatic water using the reconstitution calculator. For subcutaneous protocols, the dosage calculator helps determine accurate volumes.
