GHK-Cu Powder (Bulk)

GHK-Cu Powder (Bulk) Product Profile

GHK-Cu Powder (Bulk) is an essential laboratory and formulation supply item required for professional peptide research and cosmetic compounding applications.

Product Specifications

Parameter	Value
Composition	C14H24N6O4•Cu
Mol. Weight	404.0 g/mol
Grade	Cosmetic Grade (>98%)
Appearance	Vivid blue crystalline powder

Figure 1: GHK-Cu Powder (Bulk) Overview

Application Details

1. Provides bulk-quantity cosmetic-grade copper tripeptide-1 in raw powder form.
2. Designed for direct incorporation into custom serums, creams, and topical formulations.
3. Copper ion delivery directly activates fibroblast collagen Type I and III synthesis.
4. Simultaneously suppresses metalloproteinase activity preventing existing collagen breakdown.
5. Promotes angiogenesis and microcirculation improvement in topically applied dermal zones.

Figure 2: Quality Metrics

Key Notes

• 1: The gold-standard raw material for compounding custom anti-aging skin formulations.
• 2: 10g quantity enables large-batch production of research-grade topical preparations.
• 3: Must be dissolved in distilled water or appropriate carrier at 0.05-1% concentration.

Formulation & Compounding Applications

GHK-Cu raw powder is supplied for incorporation into custom topical formulations, serums, and cream bases. Because copper peptide is inherently water-soluble, it integrates readily into aqueous phases without the need for co-solvents. Formulators typically target final concentrations between 0.5–2% w/v, although higher concentrations have been employed in concentrated ampoule preparations.

1. Dissolve the required mass of GHK-Cu powder into distilled or deionized water at room temperature.
2. Adjust the solution pH to 5.5–6.0 using dilute sodium hydroxide or citric acid buffer to maintain peptide stability and skin compatibility.
3. Incorporate the aqueous peptide phase into your emulsion, gel, or serum base during the cool-down stage (below 40°C) to preserve bioactivity.
4. Add a broad-spectrum preservative system (e.g., phenoxyethanol & ethylhexylglycerin at 0.8–1.0%) since peptide solutions are susceptible to microbial growth.
5. Store the finished product at 2–8°C and protect from direct UV exposure to maximize shelf life.

Researched Benefits in Dermal Science

• Collagen Remodeling: Preclinical data demonstrate GHK-Cu upregulates Type I and Type III collagen synthesis in fibroblast cultures, contributing to improved dermal tensile strength and elasticity.
• Antioxidant Defense: The copper ion acts as a cofactor for superoxide dismutase (SOD), neutralizing reactive oxygen species that accelerate photoaging and hyperpigmentation.
• Wound Closure: In vitro scratch assays show accelerated keratinocyte migration at GHK-Cu concentrations as low as 1 μM, suggesting utility in post-procedure recovery formulations.
• Anti-Inflammatory Signaling: GHK-Cu suppresses NF-κB-mediated cytokine expression, reducing localized erythema and irritation in compromised skin barrier models.
• Hair Follicle Stimulation: Topical application in rodent models has shown enlargement of hair follicle size and prolongation of the anagen (growth) phase.

Storage & Handling

Bulk GHK-Cu powder should be stored desiccated at −20°C for long-term stability or 2–8°C for working stock. The lyophilized form is stable for 24+ months under these conditions. Avoid repeated freeze-thaw cycles once reconstituted. Copper peptides are light-sensitive; amber glass or opaque containers are recommended for storage of both raw powder and finished formulations.